Bewerber:
Prof. Dr. Karsten König, JenLab GmbH, Deutschland

Abstract:
In vivo high resolution multi-photon tomography for medical diagnosis of skin cancer as well as in situ detection of pharmaceutical and cosmetical components was developed by the applicant. The tomograph employs picojoule near infrared femtosecond laser pulses, flying spot technology, and single photon counting. It provides optical biopsies with intratissue submicron resolution, picosecond temporal resolution and 10 nm spectral resolution and is based on the two-photon excitation of endogenous and exogenous fluorophores as well as second harmonic generation of collagen structures. More than 1000 volunteers and patients have been investigated in Australia, Japan and Europe. Major studies include the early detection of malignant melanoma, chemotherapeutical agents and sunscreen nanoparticles in the skin, as well as the input of smoking, UV radiation and anti-aging drugs.